In vivo and in vitro Hyperglycaemic Screening of Adenocalymma alliaceum Miers, A Promising Herb

Abstract: Background: Ajos sacha is a shrubby herb and has attracted scientists’ attention due to its antioxidative, antineoplastic, larvicidal, antibacterial properties. Hence, assessed in vitro vivo diabetes protective Materials Methods: The methodology started with the quantitative phytochemical estimation of ethanolic extract Adenocalymma alliaceum (EEAA). Then, was studied for cytotoxicity, glucose utilization, GLUT-4 redistribution. In study, comprising six groups Wistar rats. Different parameters diabetes, antioxidant properties, lipid profile were performed. Results: Phytochemical screening demonstrated positive results phenolic compounds, tannins, flavonoids. EEAA found minimal level toxicity, no dosages tested causing 50% cell death. had shown redistribution assay dose-dependent manner on line procedure. After NOAEL acute level, metabolic symptoms, serum creatinine, urea, normal under treatment, bodyweight, high-density lipoprotein, protein levels increased. liver homogenate included more antioxidative enzymes such as glutathione, catalase, superoxide dismutase. histopathological analysis also reveals EEAA’s ability protect pancreatic β-cell from damage. Conclusion: current investigation blossoms restore abnormalities body. Keywords: β-cell, Alloxan monohydrate, alliaceum, Glucose redistribution, Diabetes Mellitus.